[200117 Àú³Î¹ßÇ¥] Microglial microRNAs mediate sex-specific responses to tau pathology ±èµ¿±Ô ¦¢ 2020-01-16 HIT 54791 |
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Microglial microRNAs Mediate Sex-Specific Responses to Tau PathologyAbstractSex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner. |
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