[220617 Àú³Î¹ßÇ¥] Excessive local host-graft connectivity in aging and amyloid-loaded brain ÇÑÁöÈñ ¦¢ 2022-06-14 HIT 47639 |
---|
Excessive local host-graft connectivity in aging and amyloid-loaded brain SCIENCE ADVANCES 10 Jun 2022 Vol 8, Issue 23 AbstractTransplantation is a clinically relevant approach for brain repair, but much remains to be understood about influences of the disease environment on transplant connectivity. To explore the effect of amyloid pathology in Alzheimer¡¯s disease (AD) and aging, we examined graft connectivity using monosynaptic rabies virus tracing in APP/PS1 mice and in 16- to 18-month-old wild-type (WT) mice. Transplanted neurons differentiated within 4 weeks and integrated well into the host visual cortex, receiving input from the appropriate brain regions for this area. Unexpectedly, we found a prominent several-fold increase in local inputs, in both amyloid-loaded and aged environments. State-of-the-art deep proteome analysis using mass spectrometry highlights complement system activation as a common denominator of environments promoting excessive local input connectivity. These data therefore reveal the key role of the host pathology in shaping the input connectome, calling for caution in extrapolating results from one pathological condition to another. |
Prev | [220610 Àú³Î¹ßÇ¥] Faulty autolysosome acidification in Alzheimer's disease mouse... |
---|---|
Next | [220617 Àú³Î¹ßÇ¥] Divergent Cortical Tau Positron Emission Tomography Patterns A... |