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Blockade of STING activation alleviates microglial dysfunction and a broad spectrum of Alzheimer's disease pathologies
Chung S, Jeong JH, Park JC, Han JW, Lee Y, Kim JI, Mook-Jung I. Exp Mol Med. 2024 Sep 2. -
Brain hypothyroidism silences the immune response of microglia in Alzheimer's disease animal model
Kim DK, Choi H, Lee W, Choi H, Hong SB, Jeong JH, Han J, Han JW, Ryu H, Kim JI, Mook-Jung I. Sci Adv. 2024 Mar 15;10(11):eadi1863. -
Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2
Park JC, Han JW, Lee W, Kim J, Lee SE, Lee D, Choi H, Han J, Kang YJ, Diep YN, Cho H, Kang R, Yu WJ, Lee J, Choi M, Im SW, Kim JI, Mook-Jung I. Adv Sci (Weinh). 2024 Jul 9:e2400064. -
FGFR3 drives Aβ-induced tau uptake
Kim DK, Suh K, Park J, Lee SE, Han J, Chang S, Kim Y, Mook-Jung I.Exp Mol Med. 2024 Jul 1. -
Functional effects of gut microbiota-derived metabolites in Alzheimer's disease
Hyunjung Choi, Inhee Mook-Jung. Curr Opin Neurobiol. 2023 Aug:81:102730. -
Lipid fuel for hungry-angry microglia
Choi H, Mook-Jung I. Nat Metab. 2022 Oct;4(10):1223-1224. -
A logical network-based drug-screening platform for Alzheimer's disease representing pathological features of human brain organoids
Jong-Chan Park , So-Yeong Jang , Dongjoon Lee , Jeongha Lee , Uiryong Kang , Hongjun Chang , Haeng Jun Kim , Sun-Ho Han , Jinsoo Seo , Murim Choi , Dong Young Lee , Min Soo Byun , Dahyun Yi , Kwang-Hyun Cho , Inhee Mook-Jung . Nat Commun. 2021 Jan 12;12(1):280. -
Transfer of a Healthy Microbiota Reduces Amyloid and Tau Pathology in an Alzheimer's Disease Animal Model.
Min-Soo Kim , Yoonhee Kim , Hyunjung Choi , Woojin Kim , Sumyung Park , Dongjoon Lee , Dong Kyu Kim , Haeng Jun Kim , Hayoung Choi , Dong-Wook Hyun , June-Young Lee , Eun Young Choi , Dong-Sup Lee , Jin-Woo Bae , Inhee Mook-Jung. Gut. 2020 Feb;69(2):283-294. -
A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease.
Baik SH, Kang S, Lee W, Choi H, Chung S, Kim JI, Mook-Jung I. Cell Metab. 2019 Sep 3;30(3):493-507.e6.
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[240920 저널발표] Senescent glia link mitochondrial dysfunction and lipid accumulation
Nature. 2024 Jun;630(8016):475-483. doi: 10.1038/s41586-024-07516-8. Epub 2024 Jun 5.Senescent glia link mitochondrial dysfunction and lipid accumulationChina N Byrns 1 2, Alexandra E Perlegos 2 3, Karl N Miller 4, Zhecheng Jin 2, Faith R Carranza 2, Palak Manchandra 5, Connor H Beveridge 5, Caitlin E Randolph 5, V Sai Chaluvadi 1 3, Shirley L Zhang 6, Ananth R Srinivasan 2, F C Bennett 7 8, Amita Sehgal 6, Peter D Adams 4, Gaurav Chopra 5 9 10 11 12, Nancy M Bonini 13 14Affiliations AbstractSenescence is a cellular state linked to ageing and age-onset disease across many mammalian species1,2. Acutely, senescent cells promote wound healing3,4 and prevent tumour formation5; but they are also pro-inflammatory, thus chronically exacerbate tissue decline. Whereas senescent cells are active targets for anti-ageing therapy6-11, why these cells form in vivo, how they affect tissue ageing and the effect of their elimination remain unclear12,13. Here we identify naturally occurring senescent glia in ageing Drosophila brains and decipher their origin and influence. Using Activator protein 1 (AP1) activity to screen for senescence14,15, we determine that senescent glia can appear in response to neuronal mitochondrial dysfunction. In turn, senescent glia promote lipid accumulation in non-senescent glia; similar effects are seen in senescent human fibroblasts in culture. Targeting AP1 activity in senescent glia mitigates senescence biomarkers, extends fly lifespan and health span, and prevents lipid accumulation. However, these benefits come at the cost of increased oxidative damage in the brain, and neuronal mitochondrial function remains poor. Altogether, our results map the trajectory of naturally occurring senescent glia in vivo and indicate that these cells link key ageing phenomena: mitochondrial dysfunction and lipid accumulation. 2024.09.19 -
[240920 저널발표] Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies
https://www.science.org/doi/10.1126/science.abm6131 HomeScienceVol. 385, No. 6711Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologiesFull access Research Article NEURODEGENERATIONShare on 2024.09.19