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[210219]저널발표 Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory

김행준 │ 2021-02-17

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Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory

Highlights

Astrocytic ApoE vectors miRNA species that silence neuronal cholesterol biosynthesis

Astrocytic ApoE promotes acetyl-CoA, histone acetylation, and transcription in neurons

Memory consolidation is potentiated by ApoE-mediated epigenetic control in the brain

ApoE4 is less capable of metabolic and epigenetic regulation in neurons than ApoE3




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