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[220204 Àú³Î¹ßÇ¥] Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

ÇÑÁöÈñ ¦¢ 2022-01-25

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https://doi.org/10.1016/j.cell.2021.12.041



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Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

https://doi.org/10.1016/j.cell.2021.12.041Get rights and content
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Highlights

APEX-mapped Tau interactome at subcellular and amino acid levels in human neurons

Activity-dependent binding of Tau to synaptic vesicle proteins during Tau secretion

FTD mutations reduce Tau binding to mitochondria proteins and impair bioenergetics

Tau interactors modified by FTD mutation are downregulated in human tauopathy




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