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[211231 저널발표] Microglia contribute to the propagation of Aβ into unaffected brain tissue 최하영 │ 2021-12-30 HIT 46834
. 2021 Nov 22. doi: 10.1038/s41593-021-00951-0. Online ahead of print. Microglia contribute to the propagation of Aβ into unaffected brain tissue Paolo d'Errico 1 2, Stephanie Ziegler-Waldkirch 1 2, Vanessa Aires 1 3, Philippe Hoffmann 1 2, Charlotte Mezö 3 4, Daniel Erny 2 4 5, Laura Sebastian Monasor 6, Sabine Liebscher 7 8 9, Vidhya M Ravi 2 10 11 12 13, Kevin Joseph 2 10 11 13, Oliver Schnell 2 10 11 13, Katrin Kierdorf 4 14 15, Ori Staszewski 2 4 5, Sabina Tahirovic 6, Marco Prinz 2 4 15 16, Melanie Meyer-Luehmann 17 18 19 Affiliations PMID: 34811521 DOI: 10.1038/s41593-021-00951-0 Abstract Microglia appear activated in the vicinity of amyloid beta (Aβ) plaques, but whether microglia contribute to Aβ propagation into unaffected brain regions remains unknown. Using transplantation of wild-type (WT) neurons, we show that Aβ enters WT grafts, and that this is accompanied by microglia infiltration. Manipulation of microglia function reduced Aβ deposition within grafts. Furthermore, in vivo imaging identified microglia as carriers of Aβ pathology in previously unaffected tissue. Our data thus argue for a hitherto unexplored mechanism of Aβ propagation.

[211231 저널발표] Microglia contribute to the propagation of Aβ into unaffected brain tissue

최하영 │ 2021-12-30

HIT

46834

. 2021 Nov 22.

doi: 10.1038/s41593-021-00951-0. Online ahead of print.

Microglia contribute to the propagation of Aβ into unaffected brain tissue

Affiliations

PMID: 34811521

DOI: 10.1038/s41593-021-00951-0

Abstract

Microglia appear activated in the vicinity of amyloid beta (Aβ) plaques, but whether microglia contribute to Aβ propagation into unaffected brain regions remains unknown. Using transplantation of wild-type (WT) neurons, we show that Aβ enters WT grafts, and that this is accompanied by microglia infiltration. Manipulation of microglia function reduced Aβ deposition within grafts. Furthermore, in vivo imaging identified microglia as carriers of Aβ pathology in previously unaffected tissue. Our data thus argue for a hitherto unexplored mechanism of Aβ propagation.

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